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Elisabetta Flex Selected Research

SH2 Domain-Containing Protein Tyrosine Phosphatases

1/2021Compound heterozygosity for PTPN11 variants in a subject with Noonan syndrome provides insights into the mechanism of SHP2-related disorders.
1/2017Structural, Functional, and Clinical Characterization of a Novel PTPN11 Mutation Cluster Underlying Noonan Syndrome.

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Elisabetta Flex Research Topics

Disease

8Noonan Syndrome (Female Pseudo-Turner Syndrome)
01/2021 - 02/2006
7Neoplasms (Cancer)
11/2021 - 04/2006
2LEOPARD Syndrome (Syndrome, LEOPARD)
01/2021 - 02/2006
2Carcinogenesis
01/2020 - 10/2015
2Intellectual Disability (Idiocy)
01/2019 - 10/2016
2Neurodegenerative Diseases (Neurodegenerative Disease)
10/2016 - 10/2016
2Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
11/2015 - 03/2009
2Insulin Resistance
12/2007 - 09/2005
2Glioma (Gliomas)
04/2006 - 03/2003
1Hyperglycemia
01/2022
1Rare Diseases (Rare Disease)
11/2021
1Facies
01/2019
1Cognitive Dysfunction
01/2019
1Costello Syndrome
01/2017
1Brain Diseases (Brain Disorder)
10/2016
1Type 1 Kenny-Caffey syndrome
10/2016
1Atrophy
10/2016
1Hypoparathyroidism
10/2016
1Microcephaly
10/2016
1Optic Atrophy
10/2016
1Quadriplegia (Spastic Quadriplegia)
10/2016
1Seizures (Absence Seizure)
10/2016
1Heart Failure
06/2014
1Kaufman oculocerebrofacial syndrome
08/2013
1Noonan-Like Syndrome With Loose Anagen Hair
09/2009
1T-Cell Lymphoma (Lymphoma, T Cell)
04/2008
1Metabolic Syndrome (Dysmetabolic Syndrome X)
12/2007
1Obesity
05/2007
1Rhabdomyosarcoma
04/2006
1Melanoma (Melanoma, Malignant)
04/2006
1Neuroblastoma
04/2006
1Leukemia
02/2006
1Type 2 Diabetes Mellitus (MODY)
09/2005
1Oculodentodigital Dysplasia
03/2004
1Hallermann's Syndrome (Hallermann Streiff Syndrome)
03/2004
1Congenital Structural Myopathies (Centronuclear Myopathy)
06/2002

Drug/Important Bio-Agent (IBA)

3Proteins (Proteins, Gene)FDA Link
11/2021 - 02/2006
3Protein Tyrosine PhosphatasesIBA
08/2012 - 02/2006
2SH2 Domain-Containing Protein Tyrosine PhosphatasesIBA
01/2021 - 01/2017
2Hormones (Hormone)IBA
01/2019 - 12/2007
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2019 - 09/2009
2GTP Phosphohydrolases (GTPases)IBA
01/2017 - 08/2014
2TubulinIBA
10/2016 - 10/2016
2Insulin (Novolin)FDA Link
12/2007 - 09/2005
1Malate Dehydrogenase (Dehydrogenase, Malate)IBA
01/2022
1Non-Receptor Type 11 Protein Tyrosine PhosphataseIBA
11/2021
1Biological ProductsIBA
01/2021
1Mitogen-Activated Protein Kinase 1 (p42 MAP Kinase)IBA
01/2020
1Protein Kinases (Protein Kinase)IBA
01/2020
1Phosphotransferases (Kinase)IBA
01/2020
1CytokinesIBA
01/2019
1Histones (Histone)IBA
01/2019
1ChromatinIBA
01/2019
1Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
10/2016
1Protein Isoforms (Isoforms)IBA
10/2016
1Cytokine Receptors (Cytokine Receptor)IBA
11/2015
1Janus Kinase InhibitorsIBA
11/2015
1Janus Kinase 3IBA
11/2015
1MicroRNAs (MicroRNA)IBA
10/2015
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
08/2014
1Sirolimus (Rapamycin)FDA Link
06/2014
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
08/2013
1Codon (Codons)IBA
08/2012
1Janus KinasesIBA
03/2009
1Interleukin-9 Receptors (Interleukin 9 Receptor)IBA
03/2009
1InterleukinsIBA
04/2008
1Dexamethasone (Maxidex)FDA LinkGeneric
04/2008
1Triiodothyronine (Liothyronine)FDA LinkGeneric
12/2007
1Transcription Factors (Transcription Factor)IBA
12/2007
1Iodide Peroxidase (Deiodinase)IBA
12/2007
1Peroxisome Proliferator-Activated Receptors (PPAR)IBA
12/2007
1PPAR gammaIBA
12/2007
1Glycerol (Glycerine)FDA LinkGeneric
05/2007
1Aquaporins (Water Channels)IBA
05/2007
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
04/2006
1disodium salt olean-11,13(18)-diene-3,30-diol dihemiphthalateIBA
03/2004
1Leucine (L-Leucine)FDA Link
03/2003
1myotubularinIBA
06/2002

Therapy/Procedure

2Therapeutics
11/2021 - 01/2019